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KMID : 0355319920150010093
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Journal of Korean Academy of Oral Pathology
1992 Volume.15 No. 1 p.93 ~ p.104
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AN IMMUNOHISTOCHEMICAL STUDY ON THE DISTRIBUTION OF KERATIN ON ORAL EPITHELIAL TUMORS
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1최홍란/1Hong-Ran Choi
2조규혁/2Kyu-Hyuk Cho
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Abstract
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-Abstract-
The keratins are a group of water-insoluble proteins that form 10nm
desmosome-associated tonofilaments in all epithelia and used as a sensitive marker for
epidermal differentiation. Kreatin expressions may be affected by various factors and the
pattern of expression was concerned with the distribution of keratins in benign and
malignant lesions. In this study, immunohistochemical examination was performed to
detect cytokeratin patterns in epithlial neoplasms of oral regions known to be associated
with human papillomavirus and results obtained are as follows.
1. AE1 antibody was diffusely stained in all layers of inverted papilloma and verrucous
carcinoma, but in papilloma, AE1 antibody was restricted in suprabasal layer. In
squamous cell carcinoma, cells with variable staining intensity were present in highly
disorganized fashion.
2. CK19 antibody was restricted to the basal layers in some of papilloma and inverted
papilloma. From the above results, we observed that the distribution of AE1 antibody
was correlated with benign and malignant differentiation, CK19 antibody would prove
helpful for confirmation of virus infected tumors.
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KEYWORD
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